2018 Chemical Biology Program Retreat

CBP Trainees

September 15-16, 2018

Granlibakken Tahoe
725 Granlibakken Road
Tahoe City, CA 96145



Registration Fee

The registration fee includes overnight lodging and four meals (lunch and dinner on Saturday; breakfast and lunch on Sunday). Please make checks payable to "Regents of the University of California." Cash or credit card are not accepted.

  • Graduate Students/Postdocs: $40 (register and pay by August 14) or $60 (after August 14, based on availability)
  • Faculty: $100

The rate for students/postdocs is based on double occupancy.  Students/postdocs who wish to have their own room may pay a $67.20 surcharge ($107.20 total).  Students who wish to room with a guest or spouse may pay a $151.20 surcharge ($191.20 total).  Your guest/spouse may join the group for all meals.  These rates increase by $20 after August 14.

The rate for faculty is regardless of single or double occupancy.  Faculty may pay an additional $84 for a guest/spouse ($184.00 total).  Your guest/spouse may join the group for all meals.



Tentative Schedule

Saturday, September 15

  • 12:00 PM - 1:30 PM: Lunch
  • 1:30 PM - 4:00 PM: Welcome, Student Talks
  • 4:00 PM - 6:00 PM: Break, check-in to rooms
  • 6:00 PM - 7:30 PM: Dinner
  • 7:30 PM - 8:30 PM: Keynote Talk (Ben Shen, The Scripps Research Institute, Florida Campus)
  • 8:30 PM - 9:30 PM: Poster Session and Cocktail Hour

Sunday, September 16

  • 7:30 AM - 9:00 AM: Breakfast
  • 9:00 AM - 12:00 PM: Student Talks, Breakout Sessions
  • 12:00 PM - 1:30 PM: Lunch



Natural Products as Inspirations for Chemistry, Enzymology, and Drug Discovery

Ben Shen
Department of Chemistry, Department of Molecular Medicine, and Natural Products Library Initiative at The Scripps Research Institute, The Scripps Research Institute, Jupiter, FL 33458, USA

Email: shenb@scripps.edu

Natural products are among the best sources of drugs and drug leads and serve as outstanding small molecule probes for dissecting fundamental biological processes. Natural product biosynthesis continues to push the frontier of modern chemistry, biochemistry, and molecular biology by revealing novel chemical reactions, complex enzyme systems, and intricate regulatory mechanisms. The progress made in the last two decades in connecting natural products to the genes that encode their biosynthesis has fundamentally changed the landscape of natural products research and sparked the emergence of a suite of contemporary approaches to natural products discovery. Combinatorial biosynthesis has made it possible to produce designer analogues by rational metabolic pathway engineering. Genome mining has allowed targeted discovery natural product scaffolds by exploring the vast combinatorial biosynthesis repertoire found in Nature. Selected examples from our current research will be presented to showcase natural products as inspirations for novel chemistry, enzymology, and drug discovery.


2018 CBP Retreat Keynote Speaker Ben ShenBorn and raised in China, Ben received B.Sc. from Hangzhou University (1982) and M.S. from the Chinese Academy of Sciences (under the late Prof. Chutsin Liu, 1984), both in chemistry. Ben came to the U.S. in 1986 to pursue graduate education in natural product biosynthesis, received Ph.D. in organic chemistry and biochemistry from Oregon State University (under Prof. Steven J. Gould, 1991), and carried out postdoctoral research in molecular biology and biochemistry at University of Wisconsin-Madison (under the late Prof. C. Richard Hutchinson, 1991-1995). Ben served on the faculty at the University of California, Davis (Department of Chemistry, 1995-2001) and University of Wisconsin-Madison (School of Pharmacy and Department of Chemistry, 2001-2010) before joining The Scripps Research Institute (TSRI) in 2011. Currently, Ben is Professor of Chemistry and Molecular Medicine and serves as the Chair of the Department of Chemistry for the TSRI Jupiter campus and Director of Natural Products Library Initiative at TSRI. Current research in the Shen Lab includes chemistry, biochemistry, and genetics of natural product biosynthesis and engineering in actinomycetes, natural product discovery from underexplored microorganisms, and natural product-based anticancer and anti-infective drug discovery. The Shen lab has authored >250 publications and 11 published patents (http://www.scripps.edu/research/faculty/shen).